This from the recently help International LiDAR Mapping Forum (ILMF)  in Denver, Colorado a GISuser.com LiDARnews video interview with Robert Parker, Sales Engineer at Lizardtech.

About Lizardtech LiDAR compressor - If storage requirements are critical, you can reduce your LiDAR file sizes by 90 percent or more by choosing a higher compression ratio and letting LiDAR Compressor select the best way to reach a desired file size (lossy compression). Unlike raw LAS or ASCII data, LiDAR files compressed to MrSID are easily managed resources you can extract derivatives from again and again - see also lizardtech.com for more about their solutions. See the video on the GISuser Youtube Channel